Abstract

Objective To explore clinical significance and diversification of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in serum of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with pulmonary tuberculosis. Methods The study subjects were divided into AECOPD with pulmonary tuberculosis group, AECOPD group, pulmonary tuberculosis group and healthy control group.According to imaging findings in patients with pulmonary tuberculosis, patients were divided into unilateral lesion group, bilateral lesion group, free cavity group and cavity group.According to the situation of AECOPD with pulmonary tuberculosis, patients were divided into improved group and deterioration group after treatment.IL-6, TNF-α and IFN-γ levels in serum of each group were detected by ELISA method. Results IL-6 and TNF-α levels in serum of AECOPD with pulmonary tuberculosis group were significantly higher than AECOPD group and tuberculosis group (P<0.05). IL-6, TNF-α and IFN-γ levels in patients with unilateral lesion group were significantly lower than bilateral lesion group (P<0.05). IL-6, TNF-α and IFN-γ levels in patients with free cavity group were significantly lower than cavity group (P<0.05). IL-6, TNF-α and IFN-γ levels after treatment in improved group were significantly lower than that before treatment (P<0.05). Conclusions IL-6, TNF-α and IFN-γ play a role in the pathogenesis of AECOPD with pulmonary tuberculosis.The dynamic changes of the serum level can reflect the development and prognosis of AECOPD with pulmonary tuberculosis in a certain degree. Key words: Acute exacerbation of chronic obstructive pulmonary disease; Tuberculosis; Interleukin-6; Tumor necrosis factor-α; Interferon-γ

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