Clinical, serologic, and histologic features of gluten sensitivity in children.

Abstract

R Francavilla, F Cristofori, S Castellaneta. J Pediatr. 2014;164(3):463–467.e1 The goal of this study was to evaluate the characteristics of gluten sensitivity in children. The study included 15 children (10 boys, 5 girls) with a median age of 10.3 years (range: 1.6–15 years) who were diagnosed at 2 pediatric gastroenterology tertiary centers in Italy. Patients were referred for excluding an adverse food reaction to wheat. The diagnosis of gluten sensitivity was made after symptoms were associated with wheat ingestion despite a negative celiac disease evaluation. All children included in this case series tested negative for IgA endomysial antibodies, IgA tissue transglutaminase antibodies, wheat-specific IgE, gluten-specific IgE, skin prick testing to wheat, and atopy patch testing to wheat. A …