Clinical role of triggers and modulation factors of ventricular arrhythmogenesis in stable coronary artery disease

Abstract

Ventricular arrhythmias are more commonly associated with coronary artery disease. However, ventricular arrhythmogenesis can be initiated by various trigger factors against its background. The substrate of arrhythmias in various nosological forms of stable coronary heart disease is heterogeneous. The patient may have stable exertional angina without severe fibrosis or have a history of myocardial infarction with significant scarring. Therefore the predictive value and prognostic significant of ventricular arrhythmias is not always unambiguous. Thus, for the successful treatment of arrhythmias as a main component of the prevention of sudden cardiac death, an individualized pathogenetic approach is the most important. The purpose of this article is to analyze and clinically interpret the results of studies, publications for 1980-2023, in which the authors describe the etiological, pathophysiological, pathomorphological characteristics of ventricular arrhythmias and their predictive value and prognostic significant for patients with stable coronary artery disease.