CLINICAL RISK FACTORS FOR CARDIAC SARCOIDOSIS

Abstract

SESSION TITLE: Wednesday Abstract Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/23/2019 09:45 AM - 10:45 AM PURPOSE: Identification of risk factors associated with cardiac sarcoidosis. METHODS: Retrospective case control study with prospective follow up including 598 patients with biopsy proven sarcoidosis involving multi organs except cardiac involvement and 32 patients with cardiac sarcoidosis. Thorough chart review was done for all the cases and controls and data was collected for variables including demographics, diagnostic studies and treatment details. RESULTS: Univariate analysis was done using the SPSS program. There were no significant statistical differences for age, race, gender (P >0.05). We found significant differences between group in FEV1 % (p =0.022), FEV1/FVC (p=0.012), whereas there were no differences in FVC, DLCO, TLC (P value >0.05). We found significant difference in CRP (P=0.000), while ACE and Pro-BNP levels (p>0.05) were not significant. RVSP was elevated in cardiac sarcoidosis group (p= 0.011). Furthermore, OSA (P =0.002) and DM (p=0.000) were found to be associated with cardiac sarcoidosis. Patients with cardiac sarcoidosis were on long term oxygen therapy (P=0.000). However, co morbidities including asthma, HTN, anemia were not statistically significant (p>0.05) CONCLUSIONS: Elevated CRP levels, worsening lung volumes including FEV1/FVC and FEV1, long term oxygen therapy, OSA and DM and elevated RVSP on transthoracic echo are associated with cardiac sarcoidosis. CLINICAL IMPLICATIONS: CRP values can be used as an early diagnostic marker for cardiac sarcoidosis. Patients with OSA, elevated RVSP on TTE, those on Long term oxygen therapy and with worsening lung volumes on PFT’s could be monitored closely for progression to cardiac sarcoidosis, hence decreasing the incidence of sudden cardiac death associated with Cardiac sarcoidosis. DISCLOSURES: No relevant relationships by asil daoud, source=Web Response No relevant relationships by Amina Pervaiz, source=Web Response No relevant relationships by Lobelia Samavati, source=Web Response