Abstract
Intravascular catheters have become essential devices for the management of critically and chronically ill patients. However, their use is often associated with serious infectious complications, mostly catheter-related bloodstream infection (CRBSI), resulting in significant morbidity, increased duration of hospitalization, and additional medical costs. The majority of CRBSIs are associated with central venous catheters (CVCs), and the relative risk for CRBSI is significantly greater with CVCs than with peripheral venous catheters. However, most CVC-related infections are preventable, and different measures have been implemented to reduce the risk for CRBSI, including maximal barrier precautions during catheter insertion, catheter site maintenance, and hub handling. The focus of the present review is on new technologies for preventing infections that are directed at CVCs. New preventive strategies that have been shown to be effective in reducing risk for CRBSI, including the use of catheters and dressings impregnated with antiseptics or antibiotics, the use of new hub models, and the use of antibiotic lock solutions, are briefly described.
Highlights
Intravascular catheters represent an essential part of the management of critically and chronically ill patients
Their use is often complicated by serious infections, mostly catheter-related bloodstream infections (CRBSIs), which are associated with increased morbidity, duration of hospitalisation, and additional medical costs
In the present review the new technologies for prevention of infections directed at central venous catheters (CVCs), which have been shown to reduce the risk of CRBSI, including catheters and dressings impregnated with antiseptics or antibiotics, new hub models, and antibiotic lock solutions, are briefly described (Table 1)
Summary
Intravascular catheters represent an essential part of the management of critically and chronically ill patients Their use is often complicated by serious infections, mostly catheter-related bloodstream infections (CRBSIs), which are associated with increased morbidity, duration of hospitalisation, and additional medical costs. Different measures have been implemented to reduce the risk For short-term CVCs (i.e. those in place 10 days), in which endoluminal spread from the hub appears to be the primary mechanism of infection, technologies that reduce endoluminal colonization in addition to extraluminal invasion of the catheter should provide additional protection against CRBSI
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