Abstract
BackgroundGenetic polymorphisms are commonly associated with altered transcriptional activity and possibly make individuals more susceptible to periodontal disease development, increased disease severity and poor treatment outcome. The study aimed to determine the effect of Interleukin-6 (IL-6) -572 G/C (rs1800796) and IL-10 -592 C/A (rs1800872) polymorphisms on the outcomes of non-surgical periodontal therapy in a Caucasian population.Material and MethodsSixty-eight patients with chronic periodontal disease were grouped according to their genotype: IL-6, IL-10, IL-6 and IL-10 susceptible (SCP) and non-susceptible (NSCP). All individuals were clinically evaluated at the first visit, and blood sample were collected from patients after checking the inclusion and exclusion criteria of the study. All patients received non-surgical periodontal therapy from a single-blinded periodontist. Clinical periodontal measurements were repeated 45 days after therapy.ResultsThis population mean aged 47.63 years included 52.2% females and 58.2% non-smokers. Following DNA separation and genotyping, 65.7% of patients were homozygous carriers of the IL-6 - 572G; 49.3% were carriers of the IL-10 -592A- allele (AA and CA genotypes); and 35.8% carried SCP genotypes for both polymorphisms. The clinical parameters after therapy were not associated with the genotype status. The multiple logistic regression analysis did not show any statistically significant association between the genotypes and the variables tested.Conclusions Within the limitations of this longitudinal study, it can be suggested that IL-6 -572 G/C and IL-10 -592 C/A polymorphisms as well as their combination do not influence the outcome of nonsurgical periodontal therapy in Caucasian patients diagnosed with chronic periodontal disease. Key words:Gene polymorphism, genetics, interleukins, periodontal disease, treatment outcome.
Highlights
Periodontal disease is defined as a multifactorial inflammatory disease that is marked by destruction of the supporting tissues around teeth including periodontal ligament, cementum, alveolar bone and it is the major cause of tooth loss if left untreated [1]
The hypothesis was that individuals susceptible to chronic periodontal disease would demonstrate decreased treatment response to non-surgical periodontal therapy compared to non-susceptible individuals
The results of our study suggest that IL-6 -572 G/C and IL-10 -592 C/A polymorphisms as well as their combination do not influence the periodontal treatment outcome
Summary
Periodontal disease is defined as a multifactorial inflammatory disease that is marked by destruction of the supporting tissues around teeth including periodontal ligament, cementum, alveolar bone and it is the major cause of tooth loss if left untreated [1]. In a study with postmenopausal Japanese women, it was revealed that IL-6 -572 G/C polymorphism may have an association between periodontitis and low truncal bone mineral density [13] Both meta-analyses that aimed to clarify the association between IL-6 -572 G/C polymorphism and periodontal disease susceptibility revealed a significant increased risk of chronic periodontitis in patients with GG genotype [6,7]. The limited number of the included studies as well as the lack of methodologically sound studies led to the conclusion that the clinical outcome as assessed by bleeding on probing, clinical attachment loss and plaque index, after non-surgical periodontal treatment was not associated with the genotype status of the patients with chronic periodontitis. Conclusions: Within the limitations of this longitudinal study, it can be suggested that IL-6 -572 G/C and IL-10 -592 C/A polymorphisms as well as their combination do not influence the outcome of nonsurgical periodontal therapy in Caucasian patients diagnosed with chronic periodontal disease
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