Abstract
T-large granular lymphocytic leukemia (T-LGLL) is a rare T lymphocyte proliferative disease, and its clinical manifestations are splenomegaly, neutropenia and autoimmune diseases such as rheumatoid arthritis (RA). The pathogenesis of T-LGLL is to activate survival signaling pathway and inhibit apoptotic signaling pathway to maintain long-term activation of large granular lymphocytes (LGL) by chronic antigenic stimulation. Traditional treatment methods of T-LGLL are mainly immune inhibitors such as methotrexate, cyclophosphamide and other drugs, but now there are some new drugs such as tofacitinib in clinical research. Now, the clinical research progress of T-LGLL is reviewed. Key words: Leukemia, large granular lymphocytic; Etiology; Immunosuppressive agents
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