Clinical research on treatment for acute exacerbation of chronic obstructive pulmonary disease with montelukast

Abstract

Objective To investigate the effects of montelukast in treatment for acute exacerbation of chronic obstructive pulmonary disease (COPD).Methods 80 patients diagnosed as acute exacerbation of COPD (AECOPD) in our hospital were randomly and equally divided into 4 groups.Group A and group B subjects were the patients induced sputum' s eosinophilic cell count percentage ≥ 3％,and the group C and group D subjects were the patients induced sputum' s eosinophilic cell count percentage＜3％.All subjects were treated with antibiotic therapy.Montelukast sodium tablets were only given to group A and group C.After 14 days,the CAT scores,blood gas analysis,pulmonary function and induced sputum were observed.Results There were more statistical significant difference in these indicators in group A when compared with those of group B and group C after treatment (P＜0.05),such as the CAT scores,PaO2,PaCO2 and PaO2/FiO2.And FEV1 and FEV1％pre in group A were better than those in group B and group C,but there were no significant difference (P＞0.05).The induced sputum' s eosinophilic cell count percentage and CysLTs levels were decreased significantly (P＜0.01).The induced sputum' s eosinophilic cell count percentage and CysLTs levels were significantly positively correlated with the CAT scores; and they were significantly negatively correlated with FEV1,FEV 1％ pre,PaO2 and PaO2/FiO2 (P＜0.05).The eosinophilic cell count percentage was significantly positively correlated with CysLTs levels (P＜0.05).Conclusion Montelukast can improve the patients' clinical symptoms,the quality of life.blood gas and inhibit the airway inflammation in AECOPD with eosinophilic airway inflammation.Cysttrieinyl leukoenes plays an important role in it. Key words: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD); Montelukast; Induced sputum; Eosinophils; Cysttrieinyl leukoeues