Clinical research on the focal treatment for silicone oil glaucoma

Abstract

Objective To compare the effects of topical antiglaucomatous agents on silicone oil glaucoma (SOG). Methods Eyes, which SOG was diagnosed at least 1 month after silicone oil tamponade, were selected for this experiment. The patients whose intraocular pressure (IOP) was 22-30mmHg, were divided randomly into two subgroups, group A1 (treated by levobunolol hydrochloride eye drops) and subgroup A2 (treated by latanoprost eye drops). The patients whose IOP was 31-39mmHg, were divided randomly into two subgroups, group B1 (treated by both levobunolol hydrochloride and brimonidine tartrate eye drops) and subgroup B2 (treated by latanoprost and timolol maleate eye drops). The effectiveness and IOP reduction were compared after using eye drops for 3 days and 9 days. Results SOG occurred in 84 eyes. After using the eye drops for 3 days, IOP reduction was 3.95±2.57mmHg (15.62%) for 22 eyes in group A1, 6.33±3.12mmHg (24.84%) for 21 eyes in group A2, 8.28 ± 3.56 mmHg (24.58%) for 21 eyes in group B1 and 11.15 ± 4.23 mmHg (32.74%) for 20 eyes in group B2 respectively. The difference was statistically significant within group A (t =2.74, P =0.01) and group B (t =2.42, P =0.02). The number of effective cases of the four groups was 11 eyes (50%) for group A1, 15 eyes (71.43%) for group A2, 8 eyes (38.10%) for group B1 and 12 eyes (60.00%) for group B2 respectively, and the difference was not statistically significant within group A (χ2 =2.06, P =0.22) and group B (χ2 =1.97, P =0.16). After using the eye drops for 9 days, The IOP reduction was 4.18±3.25mmHg (16.19%) and 7.17±3.40mmHg (28.30%) for groups A, and 9.71±3.92mmHg (28.78%) and 13.28±3.47mmHg (39.12%) for groups B respectively. The difference was statistically significant both within group A (t =2.95, P =0.01) and group B (t =3.08, P =0.004). The number of effective cases of the four groups was 10 eyes (45.45%) for group A1, 16 eyes (76.19%) for group A2, 8 eyes (38.10%) for group B1 and 14 eyes (70.0%) for group B2 respectively, and the difference was statistically significant within group A (χ2 =4.25, P = 0.04) and group B(χ2 =4.19, P =0.04). Conclusions Alone or in combination, prostaglandin derivatives eye drops can be more effective for the treatment of SOG. Key words: Silicone oil; Secondary glaucoma; Prostaglandin derivatives eye drops