Clinical research on cognitive function impairment after acute cerebral infarction

Abstract

Objective To analyze the(ACI) relationship between infarction sites and cognitive impairment after acute cerebral infarction.Methods A total of 134 patients with first ACI and 50 healthy control subjects matched with age, sex and education level were selected.All subjects were assessed with mini-mental state examination (MMSE), clinical memory scale ( CMS), verbal fluency test ( VFT), clock drawing task ( CDT), Barthel index (B1) assessment,Haehinski ischemic scale (HIS), Hamilton depression scale (HAMD).All patients and healthy control subjects were examined with event-related potentials (ERP) P300 test.The relationship between Results of above-mentioned neuropsychological assessment and P300 findings were compared and analyzed in accordance with the neuroimaging type of cerebral infarction.Results 1.There was statistical significance in differences of scores of MMSE, CMS, VFT, CDT between middle infarction and lacunar infarction ( P 0.05 ).2.In middle infarction and small infarction subgroups: the scores of MMSE, CMS in frontal lobe infarction and temporal lobe infarction were lower than those in basal ganglia infarction, parietal lobe infarction and occipital lobe infarction; the scores of MMSE, CMS in basal ganglia infarction were lower than those in parietal lobe infarction and occipital lobe infarction, all had statistically significant differences( P 0.05 ).Conclusion The location of cerebral infarction is closely related with cognitive function impairment after ACI. Key words: Acute cerebral infarction; Cognitive function; Neuroimaging; Neuropsychology; P300