Clinical research of Ulinastatin combining with Xuebijing injection on treatment of acute respiratory distress syndrome

Abstract

Objective To investigate the clinical effects and safety of Ulinastatin combining with Xuebijing injection on treatment of acute respiratory distress syndrome (ARDS). Methods 96 ARDS patients were randomly divided into group A (treated with Ulinastatin and Xuebijing injection), group B (treated with Xuebijing injection) and control group, 32 cases were in each group. Respiratory rate, oxygen saturation and oxygenation index of the patients were observed before and after treatment, serum tumor necrosis factor-α and interleukin-6 were detected,and time in intensive care unit, total length of stay and mortality were recorded. Results Ulinastatin combining with Xuebijing injection could obviously improve respiratory function testing index of ARDS patients, decrease tumor necrosis factor-α and interleukin-6 levels,shorten the length of stay,and reduce mortality. The results were better than that in control group (P ＜ 0. 05). Conclusions Ulinastatin combining with Xuebijing injection can improve the clinical symptoms and curative effect of ARDS patients, reduce significantly mortality. Key words: Ulinastatin; Xuebijing injection; Acute respiratory distress syndrome