Clinical research of the changes of serum inflammatory response factors after carotid endarterectomy

Abstract

Objective To investigate the relationship between the changes of serum inflammatory factors and the postoperative restenosis after carotid endarterectomy. Methods From January 2010 to May 2015, 80 randomly selected patients with severe carotid stenosis admitted to the Department of Neurosurgery, Dalian Municipal Central Hospital were analyzed retrospectively. Their stenosis degree was 70%-99%. They all received eversion carotid endarterectomy (eCEA). The levels of serum high sensitive C- reactive protein, soluble intercellular adhesion molecule-1, monocyte chemokine-1were monitored at 24 h, 48 h, 72 h, 1, 2, 4, 8, 16 and 32 weeks, respectively before and after procedure, and the surgical side carotid artery ultrasonography was conducted by the professional ultrasound doctors at the same time points. Six patients with postoperative restenosis were divided into group A, and others were divided into group B. Results The levels of serum high sensitive C-reactive protein, soluble intercellular adhesion molecule-1, and monocyte chemokine-1 in group A and B after procedure increased significantly compared with those before procedure. There were significant differences (P<0.05). At 4, 8, 16 and 32 weeks after procedure, the above detection indices of group A increased significantly compared with those of group B. There were significantly differences (P<0.01). Conclusions Surgery may result in the increased serum inflammatory factors. Restenosis after carotid endarterectomy may begin to occur from the fourth weeks after carotid endarterectomy. The increased level of serum inflammatory factors may be one of the reasons of restenosis. Key words: Carotid endarterectomy; Inflammatory factors; Restenosis