Clinical research of intraperitoneal ehemohyperthermia with NRL-002 double RF tumor hyperthermia system on recurrent ovarian cancer

Abstract

Objective To study the efficacy of intraperitoneal chemohyperthermia with Double RF Tumor Hyperthermia System on recurrent ovarian cancer. Methods 22 cases of advanced recurrent ovarian cancer were infused with hot NS and DDP and VP16 in abdominal cavity, NRL-002 double RF Tumor Hyportherrnia System was applied to heat the abdominal part for 60-120 minutes. RF hyperthermia was given twice per week and chemotherapy once per week. Results The overall response rate (CR+PR) was 63.6%. The serum CA125 ratio was decreased significantly. The level of CD4/CD5 and NK cells was higher than that of pretherapy after management. The clinical beneficial response(CBR) was 81.8%. The median TIP and MST were 7.8 mouth and 18.5 month. Conclusion Intraperitoneal ehemohyporthermia with NRL-002 Double RF Tumor Hyperthermia System was an effective way to treat advanced recurrent ovarian cancer. It Can also improve life quality of patients with mild adverse effect and recommended to be applied clinically. Key words: Ovarian neoplasms; Neoplasms recurrence, local; Intraperitoneal hyperthermo chemotherapy; Prognosis