Abstract
Malignant hyperthermia (MH) is a life-threatening reaction triggered by volatile anaesthetics and succinylcholine (SC) characterized by hypercapnia, hypermetabolism and muscle breakdown. MH is commonly caused by mutations in RYR1, as is rhabdomyolysis triggered by exertion and/or pyrexia. The discrepancy between risk genotypes and actual MH incidence remains unexplained. We hypothesized that MH is a compound event, reflecting a synergistic effect of predisposing genotype, triggering anaesthetic, and exercise and/or pyrexia as modifying factors.
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