Clinical research for thulium laser vaporization enucleation of the prostate combined with traditional transurethral resection of prostate for therapy benign prostate hyperplasia larger than 80 millilitres

Abstract

Objective To evaluate the feasibility and the safety of thulium laser vaporization enucleation of prostate(TVEP) combined with traditional transurethral resection of prostate (TURP) for therapy benign prostate hyperplasia (BPH) with its volume larger than 80 millilitres. Methods Twenty-five BPH patients (volume larger than 80 millilitres) underwent TVEP combined with TURP. The operation time, intraoperative blood loss, enucleation time, cutting time, bladder irrigating time, catheterization time, perioperative and 6 months' follow-up data such as the international prostate symptom score, quality of life score, the maximum urinary flow rate, the residual urine volume and so on were observed. Results The operation time was (66±26) min. The enucleation time was (25±9) min. The cutting time was (32±8) min. The intraoperative blood loss was (140±25) ml. The bladder irrigation time was (3.0±1.0) d. The catheterization time was (5.7±1.0) d. After 6 months, the maximum urinary flow rate, residual urine volume, international prostate symptom score and quality of life score were improved: (18.7±1.7) ml/s vs. (6.8±1.7) ml/s, (18.9±1.8) ml vs. (65.7±8.1) ml, (8.7±1.6) scores vs. (25.7±4.3) scores, (1.7±1.2) scores vs. (4.7±1.1) scores, and there were significant differences (P<0.05). Urethral stricture developed in 2 patients and epididymitis happened in 3 patients. No blood transfusion events and transurethral electric cutting syndrome occurred. Conclusion TVEP combined with TURP for therapy BPH larger than 80 millilitres is safe, and the incidence of complications is low. Key words: Prostatic hyperplasia; Thulium; Lasers; Transurethral resection of prostate