Abstract
Motility-related protein-1(MRP-1) is a member of transmembranc 4 superfamily (TM4SF).Its expression level is closely related with the clinico-pathologic and prognostic parameters.Recent studies show that MRP-1 affects the proliferation, mobility and differentiation of tumor cells by regulating the signal transduc-tion pathway.It expression is suppressed or absent in most solid tumors,and it' s low expression is related with tumor invasion and metastasis.Detecting MRP-1 expression offers us new ideas, targets and evidence for early diagnosis and treatment, and prognostic analysis of malignancies. Key words: Motility-related protein-1(MRP-1); Neoplasms; Gene expression; Prognosis
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