Abstract
Osteoinductive biomaterials are synthetic ceramics of non-biological origins able to stimulate bone formation in non-bony sites (e.g. in muscle or under skin). Although the mechanism of osteoinduction by synthetic biomaterials is not yet completely understood, the pivotal role of several physico chemical parameters have been identified, i.e. surface structure at the nano- and micro- scale. Osteoinductive resorbable Calcium Phosphate (CaP) ceramics are particularly relevant as bone graft as they have a composition comparable to the inorganic component of bone, and as they can resorb overtime to be replace by bone. The superiority of osteoinductive CaP with sub-micron features has been proven in several challenging preclinical models. The preliminary clinical results show clear benefits for patients in need for bone grafting.
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