Clinical Relevance and Environmental Prevalence of Mycobacterium fortuitum Group Members. Comment on Mugetti et al. Gene Sequencing and Phylogenetic Analysis: Powerful Tools for an Improved Diagnosis of Fish Mycobacteriosis Caused by Mycobacterium fortuitum Group Members. Microorganisms 2021, 9, 797.

Ivo Pavlik,Vit Ulmann,Ross Tim Weston

doi:10.3390/microorganisms9112345

Ivo Pavlik, Vit Ulmann + Show 1 more

Open Access

https://doi.org/10.3390/microorganisms9112345

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Abstract

Mycobacterium fortuitum group (MFG) members are able to cause clinical mycobacteriosis in fish and other animals including humans. M. alvei, M. arceuilense, M. brisbanense, M. conceptionense, M. fortuitum, M. peregrinum, M. porcinum, M. senegalense, M. septicum, and M. setense were isolated from fish with mycobacteriosis. In other animals only three MFG species have been isolated: M. arceuilense from camels’ milk, M. farcinogenes from cutaneous infections often described as “farcy”, and M. fortuitum from different domestic and wild mammals’ species. Out of 17, only 3 MFG species (M. arceuilense, M. lutetiense and M. montmartrense) have never been reported in humans. A total of eight MFG members (M. alvei, M. brisbanense, M. conceptionense, M. fortuitum subsp. acetamidolyticum, M. houstonense, M. peregrinum, M. porcinum, and M. septicum) have been isolated from both pulmonary and extrathoracic locations. In extrathoracic tissues five MFG species (M. boenickei, M. farcinogenes, M. neworleansense, M. senegalense, and M. setense) have been diagnosed and only one MFG member (M. fortuitum subsp. acetamidolyticum) has been isolated from pulmonary infection.

Highlights

Faculty of Regional Development and International Studies, Mendel University in Brno, Tr
Mycobacterium fortuitum group (MFG) members as fish pathogens, another significant number of publications describe these MFG members only as saprophytic mycobacteria present in the water environment or on healthy animals including fish. To this end we have summarised published results concerning the prevalence of MFG members in the environment and their clinical relevance to humans and animals
Members (M. alvei, M. arceuilense, M. brisbanense, M. conceptionense and M. senegalense) as species isolated from fish with mycobacteriosis (Table 1)

Summary

Clinical Relevance in Fish

Mycobacterium fortuitum was first described in 1938 [2] and since that time, during last two decades in particular, the remaining MFG members have been identified (Table 1). Mugetti et al [1] described for the first time five MFG members (M. alvei, M. arceuilense, M. brisbanense, M. conceptionense and M. senegalense) as species isolated from fish with mycobacteriosis (Table 1). These five MFG species were isolated from 10 genera of freshwater fish originally living in tropical and temperate zones. Three MFG species were isolated from fish of three (M. arceuilense), four (M. conceptionense) and six (M. senegalense) genera (Table 2) This finding could indicate that these MFG members could be considered as emerging fish pathogens. This high prevalence in fish with mycobacteriosis was more frequently diagnosed in significantly earlier studies, as shown in Table 1, when diagnostics were not as sophisticated as they are [1] and it is possible that misidentification of these species has occurred in some of these cases

Clinical Relevance in Other Animals

Clinical Relevance in Humans

Environmental Prevalence

Fish granuloma diagnosed ininprofessional ontwo twoplaces places right hand: