Clinical related study progression of Parkinson’s disease combined with sleep behavior disorder

Abstract

Parkinson’s disease (PD) is usually characterized by motor symptoms including bradykinesia, rigidity, tremor, and postural instability. Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by lack of muscle atonia during REM sleep and enactment of dream content. RBD is closely associated with PD. The pathophysiological mechanisms of PD with RBD may be related to defects of nigrostriatal dopamine and locus coeruleus/sub-locus coeruleus complex in brainstem. RBD has high incidence in PD patients, mainly presented with more severe non-motor symptoms, and more prominent life ability and life quality damage. Injury prevention should be given to PD patients with RBD besides positive intervention of PD. We mainly discussed the above contents in this paper. Key words: Parkinson’s disease; Rapid eye movement sleep behavior disorder; Non-motor symptom