Abstract
Introduction. At the initiative of the Russian Hematology Society, the research group for the study of idiopathic aplastic anemia has developed clinical recommendations for the diagnosis and treatment of idiopathic aplastic anemia.Aim: to standardize diagnostic and therapeutic approaches for the treatment of acquired aplastic anemia in Russia.Methods. The methodological approaches used are based on the principles of evidence-based medicine, based on the recommendations of the Russian council of experts on the diagnosis and treatment of patients with idiopathic aplastic anemia, Russian and international experience in managing patients, and the recommendations of the European group for the study of aplastic anemia.Results. A new revised and updated version of the national clinical guidelines is presented.Conclusion. These recommendations are intended for doctors of various specialties, health administrators, and medical school students.Conflict of interest: the authors declare no conflict of interest.Financial disclosure: this study did not have sponsorship.
Highlights
At the initiative of the Russian Hematology Society, the research group for the study of idiopathic aplastic anemia has developed clinical recommendations for the diagnosis and treatment of idiopathic aplastic anemia
Основные осложнения терапии антитимоцитарного глобулина (АТГ) Аллергические и анафилактические реакции во время введения АТГ — озноб, лихорадка, эритематозная или уртикарная сыпь — встречаются у 30–60% больных
9 Антинуклеарный фактор и антитела к двуспиральной ДНК Antinuclear factor and antibodies to double-stranded DNA Панцитопения при системной красной волчанке может быть аутоиммунной с клеточным костным мозгом, ассоциироваться с миелофиброзом или редко — с гипоклеточным костным мозгом Pancytopenia in systemic lupus erythematosus may be autoimmune with cell bone marrow, associated with myelofibrosis, or rarely with hypoccellular bone marrow
Summary
Апластическая анемия (АА) — заболевание системы крови, характеризующееся панцитопенией, обусловленной аплазией костного мозга, связанной с нарушением иммунных механизмов регуляции кроветворения, количественным дефицитом и функциональными дефектами стволовых кроветворных клеток
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