Clinical, radiological, and pathological features of 33 adult unilateral thalamic gliomas.

Peng Zhang,Jinsong Han,Guidong Song,Liwei Zhang,Xingchao Wang,Xiaohui Ren,Jian Xie,Zhixian Gao,Nan Ji,Ruofei Wu

doi:10.1186/s12957-016-0820-x

Abstract

BackgroundUnilateral adult thalamic gliomas are rarely reported. In this study, the authors aimed to analyze the clinical, radiological, and pathological features of adult primary unilateral thalamus gliomas (UTGs).MethodsClinical data of 33 UTGs in adults who underwent surgical treatment between 2005 and 2014 at the Beijing Tiantan Hospital were collected and retrospectively studied. Follow-up evaluation was performed.ResultsThis study included 21 males and 12 females with a mean age of 43.1 years. The most common symptoms were headache (75.8 %, 25/33 patients) and motor deficits (42.4 %, 14/33 patients). Radiological results showed that enhancement was common (90.9 %, 30/33 patients) and included cystic appearances in 9 cases (27.3 %). All patients underwent maximal safe tumor resection. Gross total resection (GTR) was achieved in 19 cases, subtotal resection (≥80 %) in 9 cases, and partial resection (<80 %) in 5 cases. Molecular pathology results were available in 15 cases. After surgery, 25 patients received postoperative adjuvant therapy based on the remaining pathology. The median follow-up period of all 33 patients with UTGs was 17 months (1 week~49 months). Twenty-four patients experienced tumor recurrence. The 1-year and 2-year progression-free survival (PFS) rates were 49.0 and 10.2 %, respectively. The 1-year and 2-year overall survival (OS) rates were 68.1 and 25.9 %, respectively. Survival analyses revealed that several predictive factors were correlated with better prognosis, among which, GTR and tumor with cystic appearances were significantly associated with a longer survival.ConclusionsAdult UTGs displayed a wide spectrum of clinical features. GTR can be achieved in adult UTGs with acceptable complications and conferred a better prognosis. Tumor with cystic appearance may indicate better prognosis. More patients and longer follow-up periods are needed to further elucidate the biological features of adult UTGs.Electronic supplementary materialThe online version of this article (doi:10.1186/s12957-016-0820-x) contains supplementary material, which is available to authorized users.

Highlights

Unilateral adult thalamic gliomas are rarely reported
Our current study used the following inclusion criteria: (1) histological diagnosis of gliomas and (2) patient age older than 18 years at the time of diagnosis while gliomas originating from adjacent structures but secondarily involving thalamus and primary bilateral thalamic gliomas were excluded, but the contrallateral growth of a unilateral tumor was included in the study
Radiological features of patients with unilateral thalamus gliomas (UTGs) Using the selection criteria, we identified 33 patients with UTGs

Summary

Introduction

Unilateral adult thalamic gliomas are rarely reported. In this study, the authors aimed to analyze the clinical, radiological, and pathological features of adult primary unilateral thalamus gliomas (UTGs). Thalamic glomas represent 1 to 5 % of brain tumors [1,2,3,4,5,6,7]. This disease has been investigated in several studies spanning several decades. Several recent studies have revealed a more acceptable prognosis among pediatric thalamic glioma patients [15, 28, 29]. It is uncertain whether a more radical surgical procedure

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Discussion

Conclusion