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Abstract
Aim and objectivesAim of the study was to evaluate the success of magnetic nanoparticles (MNPs) as pulpotomy medicament by clinical, radiologic, and histological assessment in primary molars.Materials and methodsThe sample included 30 primary molars from 25 children aged between 3 and 9 years requiring pulpotomy treatment. Pulpotomy was carried out with MNPs. The teeth were evaluated after a period of 3, 6, and 12 months clinically and with the aid of radiographs. After 1 year, 10 teeth were extracted for histological evaluation under field emission scanning electron microscope (FE-SEM; ZEISS, Model No. Supra 55vp).ResultsOf the samples, 98% showed clinical success rate with absence of pain, swelling, mobility, and abscess formation. After 3 months, 98% radiological success with absence of periodontal ligament widening, root resorption, and inter-radicular radiolucency was noted. Histological examination carried out under FE-SEM revealed a zone of odontoblastic proliferation at the interface between MNPs and odontoblastic layer of pulp and viable pulpal cells from the canal orifice till apical foramen.ConclusionMagnetic nanoparticles can be recommended as an effective pulpotomy medicament with hard tissue barrier formation and preservation of vitality of remaining radicular pulp.How to cite this article: Konyala HR, Mareddy AR, Puppala N, Reddy NV, Mallela MK, Susheela KP. Clinical, Radiological, and Histological Assessment of Magnetic Nanoparticles as Pulpotomy Medicament in Primary Molars. Int J Clin Pediatr Dent 2018;11(4):283-287.
Highlights
Properties of magnetism are being used since decades in many medical applications
Histological examination carried out under field emission scanning electron microscope (FE-SEM) revealed a zone of odontoblastic proliferation at the interface between magnetic nanoparticles (MNPs) and odontoblastic layer of pulp and viable pulpal cells from the canal orifice till apical foramen
Magnetic nanoparticles can be recommended as an effective pulpotomy medicament with hard tissue barrier formation and preservation of vitality of remaining radicular pulp
Summary
Properties of magnetism are being used since decades in many medical applications. New advancements are being developed because of the availability of superior electromagnets, superconducting magnets, and permanent magnets.[1]Nanostructured materials have unique electrical, chemical, structural, and magnetic properties, allowing them for use in information storage, biosensing applications, and biomedical engineering.[2]. Properties of magnetism are being used since decades in many medical applications. New advancements are being developed because of the availability of superior electromagnets, superconducting magnets, and permanent magnets.[1]. Nanostructured materials have unique electrical, chemical, structural, and magnetic properties, allowing them for use in information storage, biosensing applications, and biomedical engineering.[2] Nanoparticles having magnetic properties carry great advantages by providing selective attachment to a functional molecule, confer magnetic properties to the target, and allow manipulation and transportation to a desired location through the control of a magnetic field produced by an electromagnet or permanent magnet. Medical applications include magnetic cell separation, immunoassay, hyperthermia, magnetic resonance imaging (MRI) contrast agents, target drug delivery, gene delivery, pathogen detection, and bone tissue engineering. Pulpotomy is the most common pulp treatment of primary molars
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