Clinical prognosis of myelodysplastic syndrome in the elderly and its influencing factors

Abstract

Objective To analyze the clinical prognosis and its influencing factors in elderly patients with myelodysplastic syndrome. Methods A total of 36 elderly patients with myelodysplastic syndrome were included in this study, who were diagnosed and treated at our hospital from January 2013 to August 2016.The Kaplan-Meier method was used to analyzed the survival of these patients, and the effects of gender, age, WHO classification, white blood cell count, platelet count, hemoglobin and IPSS grouping on survival were analyzed.The independent risk factors associated with the clinical prognosis of patients were identified by using multivariate Cox regression analysis. Results Patients were followed up until March 31, 2017 with a follow-up time ranging from 8 to 31 months.During the follow-up period, 19(58.3%)deaths and 17(41.7%)survivals were reported.The average survival time was(19.17±1.47)months.Kaplan-Meier survival analysis showed that age, WHO classification, white blood cell count, platelet count and IPSS grouping were closely associated with survival in elderly patients with myelodysplastic syndrome.Multivariate Cox regression analysis showed that age and IPSS grouping were independent prognostic factors in elderly patients with myelodysplastic syndrome. Conclusions Age, WHO classification, white blood cell count, platelet count and IPSS grouping are closely related to the prognosis of myelodysplastic syndrome in elderly patients. Key words: Myelodysplastic syndrome; Clinical prognosis; Risk factors