Abstract
Aim: To Study the Clinical profile of Ocular Surface Squamous Neoplasia (OSSN).
 Design: Retrospective study.
 Materials and Methods: We analysed 28 cases of OSSN who presented to the out-patient department of tertiary eye care centre Hospital, over a period of 1 year from January 2017 to January 2018.
 Results: In patients, who presented with OSSN age ranged from 24 to 70 years, mean age being 44.80 years. Males were predominantly affected accounting for 64.28%. A nodule at the libus is the commonest presentation. About 25% of the patients were positive for HIV with mean age of presentation 32 years. Among HIV positive patients 5 cases had SCC.
 Conclusion: OSSN was observed more common in males. Nodular type of lesion is the commonest variety. HIV positive individuals have an increased incidence of OSSN with invasive characteristics. Hence, ophthalmologists need to be aware of this association and a thorough workup is warranted for all patients presenting with OSSN, especially in the younger age group.
 Keywords: Ocular surface squamous neoplasia, Carcinoma in-situ(CIS), Squamous cell carcinoma (SCC)
Highlights
Ocular Surface Squamous Neoplasia (OSSN) is an encompassing term for pre-cancerous and cancerous epithelial lesions of the conjunctiva and cornea
We analysed 28 cases of OSSN who presented to the out-patient department of tertiary eye care centre Hospital, over a period of 1 year from January 2017 to January 2018
Statistical analysis showed a significant association between a young patient with OSSN and HIV status This necessitates testing for the presence of HIV in any young patient presenting with OSSN
Summary
OSSN is an encompassing term for pre-cancerous and cancerous epithelial lesions of the conjunctiva and cornea. It includes the spectrum of Dysplasia, Carcinoma in-situ (CIS) and Invasive SCC [1,2,3]. OSSN is mostly unilateral and is seen in middle age and older patients. Factors associated with the development of OSSN are exposure to sunlight, HPV type 16 infections and HIV infection [2,5]. A systemic association of the development of OSSN is Xeroderma Pigmentosum. Other factors associated are old age, heavy cigarette smoking, male sex and people of light complexion
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Medical and Biomedical Studies
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
