CLINICAL PROFILE OF MUCORMYCOSIS IN TERTIARY CARE CENTER IN NORTHERN INDIA

Abstract

Purpose: The objective of the study is to study the clinical prole of Mucormycosis in tertiary care center in Northern India. Materials And Methods: This was prospective study which analyzed patients with rhino-orbital mucormycosis, referred to our department from May 2021 to August 2021.After taking a detailed ocular and systemic history, each patient underwent a complete eye examination. Diagnosis was based on nasal swab KOH mount and fungal culture and was conrmed on MRI brain, orbit and PNS in all patients. The characteristics studied were demographic details, clinical features, predisposing factors and co-morbid illnesses. The treatment in terms of usage of antifungal (amphotericin B and posaconazole), antibiotics and surgery was also noted. Statistical Methods: Descriptive analyses were used to study the parameters. Results: A total of 138 patients of mucormycosis were referred to our department. Seventy patients were male and sixty eight patients were female. Uncontrolled diabetes mellitus was the most common underlying predisposing factor. Patients presented with wide range of symptoms of which visual disturbance was the most common symptom. 35 (25.3%) patients were treated with conventional Inj Amphotericin-B and 26 (18.8%) patients were treated with oral antifungal drug due to complications such as hypotension, elevated urea/ creatinine levels. 31 patients underwent surgical debridement of the eschar within the nose/ paranasal sinuses. 8 patients underwent orbital exenteration of the involved orbit for complete clearance of disease and to limit the spread of infection intracranially. Conclusion: Early diagnosis with pathological conrmation and aggressive surgical treatment gives a better outcome.