Abstract
Abstract Background Global burden of dengue is substantial, with an annual incidence of 50 million cases. India has witnessed gradual rise in its incidence, mainly from urban regions. North-eastern India, hitherto non-endemic for dengue, has reported sporadic cases of dengue lately. Objective To study the clinical profile of dengue in north-east India. Method and material Clinical profile of 218 dengue patients (≥15 years) was studied in a hospital-based observational study. Dengue was diagnosed by WHO criteria and confirmed by NS1 antigen and/or dengue specific IgM ELISA tests. Statistical analyses were done using SPSS and STATA Data analysis and statistical software. A ‘p value’ Results There was male preponderance (58.7%), affecting mainly younger (15–34 years) subjects (73.85%). Majority (96.33%) were without travel history, none had dengue previously. Serological confirmation was present in 77.06%. On admission, mean haemoglobin and platelet counts were low with normal leucocyte count and haematocrit. Platelet and leucocyte counts declined during hospital stay; 8.25% developed severe thrombocytopenia ( 3 ) necessitating platelet transfusion, 17.43% developed leukopenia. Systemic hypotension was found in 13.3%. Mortality was nil and average hospital stay was 5.36 days. Conclusion First attacks of dengue without travel history, in a hitherto non-endemic region suggest recent endemicity.
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