Abstract
The cases of coronavirusdisease 2019 in children have been increasing with the ongoing pandemic.The finding suggests children have mild symptoms and a short course of the disease. Angiotensinconverting enzyme-2 mediates entry of the virus into the cell, the combination of virus and ACE2 leads to an increase in activity of angiotensin II, resulting in acute injury to lungs, myocardium and other organs. The infection causes down-regulation of ACE2 expression. The ACE2 plays an important role in the infection progression and clinical characteristics of COVID-19. Works on ACE2 and virus spike protein have future prospects of strategic information on prevention, management as well as vaccine development. Keywords: children;Coronavirus Disease 2019(COVID-19);SARS-Cov-2;angiotensin-Converting Enzyme 2 (ACE2).
Highlights
In December 2019 cases of pneumonia of unknown cause reported from Wuhan, China was later found to be caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
We found that infection by SARSCoV-2 is less common in children, and has mild symptoms
Children are less affected by COVID-19 and have mild symptoms
Summary
In December 2019 cases of pneumonia of unknown cause reported from Wuhan, China was later found to be caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease casue by this novel corona virus pneumonia was named the coronavirus disease 2019 (COVID-19) by the World Health Organization.[1] This virus is a coronavirus, singlestrand positive-sense RNA virus which bears 80% similar genome sequence to that of earlier welknown SARS corona virus.[2,3,4] An outbreak of unusual pneumonia was reported in Wuhan with many cases linked to Huanan Seafood Market that sells seafood as well as live exotic animals. The COVID-19 quckly spread and was declared a pandemic of significant public health concern which has affected all 213 countries and territories around the world, with reported total cases of 17,745,673 and deaths reaching
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