Abstract

We present a case series of patients with chronic kidney disease of unknown etiology (CKDu) coming from a well-defined geographic area, Yavatmal, district of Maharashtra, in central of India. These patients presented with advanced renal failure, variable proteinuria, and bilateral hyperechoic kidneys, largely normotensive and belonged to poor economic class from agricultural communities. The study highlights the need for large epidemiological survey in Yavatmal region to detect patients with CKDu and investigate the possible etiology.

Highlights

  • Chronic kidney disease of unknown origin (CKDu) has been reported from many hotspots across the globe from central America, Egypt, Srilanka, and coastal India (1)

  • In the first report of Indian CKD Registry, CKDu is the cause of CKD in 18% of the population (2)

  • The inclusion criteria for probable CKDu were Estimated glomerular filtration rate (eGFR)< 60 mL/min with at least two eGFR readings more than 12 weeks apart or proteinuria more than 150 mg/day or urine protein creatinine ratio of more than 0.15

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Summary

Introduction

Chronic kidney disease of unknown origin (CKDu) has been reported from many hotspots across the globe from central America, Egypt, Srilanka, and coastal India (1). In the first report of Indian CKD Registry, CKDu is the cause of CKD in 18% of the population (2). The study of Global dimensions and perspectives of CKD by Jha et al have shown that the poorest populations are at the highest risk (3)

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