Clinical Profile and Outcomes of Hospitalized Coronavirus Disease-2019 Patients Requiring Renal Replacement Therapy at a Tertiary Care Center

Abstract

ABSTRACT Introduction: Patients with coronavirus disease-2019 (COVID-19) infection who have underlying chronic kidney disease (CKD) or experience acute kidney injury (AKI) are at an increased risk of severe disease and mortality. Materials and Methods: This single-center retrospective study was conducted at a tertiary care center offering hemodialysis (HD) facilities to COVID-19-positive patients. We included COVID-19-positive patients aged >18 years who received HD during their hospital stay. Patients were classified as CKD-5D, acute on CKD, and AKI stage-3 (AKI-3D). Results: Severe disease was seen in ~60% of patients, with a higher overall mortality (46.15%). However, there was no significant difference in mortality between CKD-5D (n = 70), acute on CKD (n = 32), and AKI-3D (n = 15) groups (42.9% vs. 53.1% vs. 46.7%, P = 0.627). Advanced age, diabetic status, severe disease, and raised inflammatory markers were predictors of mortality. Conclusion: Among patients with COVID-19, severe renal disease requiring dialysis is associated with high mortality. We did not see any significant difference in mortality in either AKI or CKD subgroups.