Clinical Profile and Outcome of Surgical Treatment of Perforated Peptic Ulcers in Bangladesh: A Tertiary Hospital Experience

Abstract

Introduction: Peptic ulcer disease occurs when open sores, or ulcers, form in the stomach or first part of the small intestine. Many cases of peptic ulcer disease develop because a bacterial infection eats away at the protective lining of the digestive system. People who frequently take pain relievers are more likely to develop ulcers. Aim of the study: The study aimed to evaluate the Clinical Profile and Outcome of Surgical Treatment of Perforated Peptic Ulcers in Bangladesh. Methods: This was a combined retrospective and prospective study of patients operated on for peptic ulcer perforations at Khulna Medical College Hospital Khulna, Bangladesh, from January 2021 to December 2021. The subjects of this study included all patients who were operated on for peptic ulcers at Khulna Medical College Hospital Khulna during the period under study. Result: A total of 145 patients were enrolled and analyzed. Figure-1 shows the age distribution of the study; 65(44.83%) patients were under-aged <65, 55(37.93%) patients were from the age range 65-80, and 25(17.24%) patients were under-aged >80. The gender distribution of the study is shown in figure-2. Most of them had abdominal-related problems, whereas 91(62.76%) patients were male and 54(37.24%) were female. The clinical outcomes, there is half of the patients had a blood transfusion, 14(9.66%) patients had re-bleeding, 9(6.21%) patients had surgery problems, and only 7(4.83%) patients had a 30-day mortality rate. Patients needed to stay in the hospital for around 0-45 days, where the median hospital stay is six days. Conclusion: Perforation of peptic ulcers remains a frequent clinical problem in our environment, predominantly affecting young males not known to suffer from PUD. Simple closure with an omental patch followed by Helicobacter pylori eradication was effective with excellent results in the majority of survivors despite patients’ late presentation in our centre.