Clinical prevention effect of low-dose aspirin combined with air pressure therapeutic apparatus in vein thrombosis of lower limbs after cesarean section

Abstract

Objective To investigate clinical effect of low-dose aspirin combined with air pressure therapeutic apparatus prevention of vein thrombosis of lower limbs after cesarean section. Methods From January 2010 to February 2012, a total of 200 cases of pregnant women who delivered with cesarean section in Shenzhou Hospital Affiliated to Hebei Medical University were chosen as study subjects. According to their odd and even number of admission, they were randomly divided into research group (n=100, treated by basic obstetric care and low-dose aspirin combined with air pressure therapeutic apparatus) and control group (n=100, treated by basic obstetric care without using any anticoagulants). Inclusion standards of this study: all subjects delivered by cesarean section, 18-45 years old, performed among whom signed informed consent. Exclusion standards of this study: prenatally diagnosed as coagulation impairments and hemorrhage, had disease of serious heart, hepatic, kidney, especially viscera dysfunction, received anticoagulant therapy before cesarean section, complicated with autoimmune disorders. There were no significant differences between two groups among constituent ratios of age, unipara and multipara, single birth and multifetation, and incidence rates of pregnancy complications, delivery of fetal macrosomia, average gestational age, etc. (P>0.05). There were no significant differences between two groups among correlation index of cesarean section, such as duration of operation, intraoperative blood loss volume, etc. (P>0.05). Incidence of total vein thrombosis of lower limbs after cesarean section taking different clinical intervention between two groups, resting cardiac index (CI) and swelling index of lower limbs at 7-day after cesarean sections, and visual analogue scale (VAS) scores at 3-, 7- and 14-day after cesarean sections between two groups were analyzed by statistical method. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Shenzhou Hospital Affiliated to Hebei Medical University. Informed consent was obtained from all participants. Results There was no patient had vein thrombosis of lower limbs after cesarean section in observation group, and in control group, the rate of vein thrombosis of lower limbs was 10.0% (10/100), the difference between two groups was statistical significant (χ2=10.526, P 0.05). Conclusions Low-dose aspirin combined with air pressure therapeutic apparatus has significant prevention effects in vein thrombosis of lower limbs after the cesarean surgery. This strategy can effectively decrease the incidence of vein thrombosis of lower limbs, relieve postoperative pain, reduce the injury to the heart, decrease swelling index of lower limbs, improve patient life quality and promote postoperative recovery, which should be widely applied in clinic. Key words: Air pressure therapeutic apparatus; Aspirin; Low-dose; Cesarean section; Venous thrombosis; Quality of life; Maternal