Abstract
Neonatal sepsis is of two types; early onset sepsis and late onset sepsis. Early onset sepsis (EOS) present within first 72 hours of life. In severe cases, the neonates may be symptomatic at birth. Infants with EOS usually present with respiratory distress and pneumonia. Hence based on above findings the present study was planned to evaluate the immediate clinical outcomes of culture proven neonatal sepsis in the NICU.
 The study was planned by enrolling the 320 neonates admitted in Neonatal unit of Department of Paediatrics in Nalanda Medical College and Hospital, Patna, from Dec 2017 to Jun 2018. The 40 neonates were diagnosed positive for septicemia was enrolled in the present study. The approval of the institutional committee was taken prior conduct of study. All the patients were informed consents.
 The data from the present study revealed that adequate care of the low birth weight babies is of utmost importance to prevent infection by Klebsiella pneumoniae. Amikacin should be used along with third-generation cephalosporins for empirical treatment of gram-negative neonatal sepsis. This empirical regimen should be modified later based on the antibiogram of the isolates.
 Keywords: neonatal sepsis, epidemiology, microbiology, etc.
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