Clinical predictive factors of histological chorioamnionitis: case-control study

H Zaidi,N Lamalmi,L Lahlou,M Slaoui,A Barkat,S Alamrani,Z Alhamany

doi:10.1016/j.heliyon.2020.e05698

H Zaidi, N Lamalmi + Show 5 more

Open Access

https://doi.org/10.1016/j.heliyon.2020.e05698

Copy DOI

Journal: Heliyon	Publication Date: Dec 1, 2020
Citations: 3	License type: cc-by

Affiliation: Mohammed V University, Centre Hospitalier Ibn Sina

Abstract

IntroductionHistological chorioamnionitis or "intrauterine inflammation or infection" (Triple I) it is an acute inflammation of amniotic membrane, chorionic plate and umbilical cord. SubjectTo assess in the event of the clinical predictive factors associated to histological chorioamnionitis. MethodsProspective examination of 50 placentas from aberrant pregnancies, and 50 placentas from 'normal' deliveries. The Placentas analyzed by the conventional histopathology method, and the severity of chorioamnionitis was classified histologically according to the intensity and the topography of placental inflammation.The clinical and histopathological features of the study groups were introduced into the SPSS 13 database (License University Mohammed V-Rabat). Results36/50 placentas of aberrant pregnancies showed a histological chorioamnionitis often associated to a funisitis, and 11/50 normal placentas have shown some lesions of histological chorioamnionitis mainly grade one without funisitis.On the other hand we noted a statistically significant association between histological chorioamnionitis and premature rupture of the membranes (PROM) over than 12h (p < 0.001). ConclusionsOur study confirmed the predominance of histological chorioamnionitis lesions in clinically suspected cases of chorioamnionitis with 72% versus 22% in the controls group.Among the clinical parameters studied, only the premature rupture of the Membranes was shown a statistically significant association with the appearance of histological signs of chorioamnionitis.In conclusion, chorioamnionitis is sometimes clinically silent. Morphological placental study could be a confirmation of this pathology, which is predominantly associated to PROM over than 12 h.

Highlights

Histological chorioamnionitis or "intrauterine inflammation or infection" (Triple I) it is an acute inflammation of amniotic membrane, chorionic plate and umbilical cord
The purpose of this study is to investigate histological chorioamnionitis and its clinical predictors through a case-control study for the first time in Moroccan patients
Clinical signs of infection such as premature rupture of the membranes (PROM), fever and stained amniotic fluid were found in 43%, 21.6% and 17.8% of our population, respectively

Summary

Introduction

Histological chorioamnionitis or "intrauterine inflammation or infection" (Triple I) it is an acute inflammation of amniotic membrane, chorionic plate and umbilical cord. The definition of histological chorioamnionitis or "inflammation or intrauterine infection" (Triple I) is acute inflammation of amniotic membranes, chorionic plate and umbilical cord most often of bacterial origin [1, 2] and it is the most common pathology during pregnancy. It is a frequent lesion, in the case of premature rupture of membranes (75%) and in the case of preterm labor with intact membranes (30%) [3]. It is described in only 0.9–10.5% of pregnancies before the presentation of the signs mentioned above [4]

Objectives

Methods

Results

Discussion

Conclusion