Abstract
BackgroundPatients with myeloma experience substantial delays in their diagnosis, which can adversely affect their prognosis.AimTo generate a clinical prediction rule to identify primary care patients who are at highest risk of myeloma.Design and settingRetrospective open cohort study using electronic health records data from the UK’s Clinical Practice Research Datalink (CPRD) between 1 January 2000 and 1 January 2014.MethodPatients from the CPRD were included in the study if they were aged ≥40 years, had two full blood counts within a year, and had no previous diagnosis of myeloma. Cases of myeloma were identified in the following 2 years. Derivation and external validation datasets were created based on geographical region. Prediction equations were estimated using Cox proportional hazards models including patient characteristics, symptoms, and blood test results. Calibration, discrimination, and clinical utility were evaluated in the validation set.ResultsOf 1 281 926 eligible patients, 737 (0.06%) were diagnosed with myeloma within 2 years. Independent predictors of myeloma included: older age; male sex; back, chest and rib pain; nosebleeds; low haemoglobin, platelets, and white cell count; and raised mean corpuscular volume, calcium, and erythrocyte sedimentation rate. A model including symptoms and full blood count had an area under the curve of 0.84 (95% CI = 0.81 to 0.87) and sensitivity of 62% (95% CI = 55% to 68%) at the highest risk decile. The corresponding statistics for a second model, which also included calcium and inflammatory markers, were an area under the curve of 0.87 (95% CI = 0.84 to 0.90) and sensitivity of 72% (95% CI = 66% to 78%).ConclusionThe implementation of these prediction rules would highlight the possibility of myeloma in patients where GPs do not suspect myeloma. Future research should focus on the prospective evaluation of further external validity and the impact on clinical practice.
Highlights
Myeloma is the second most common haematological malignancy.[1]
The implementation of these prediction rules would highlight the possibility of myeloma in patients where GPs do not suspect myeloma
Future research should focus on the prospective evaluation of further external validity and the impact on clinical practice
Summary
Myeloma mainly affects older people, with a median age at diagnosis of around 70 years.[3,4] Delays in myeloma diagnosis are common: 50% of patients with myeloma experience an interval of >3 months between first presentation to primary care with a myeloma-related symptom and diagnosis, and they consult ≥3 times in primary care before referral to secondary care.[5,6] Delays in diagnosis are associated with advancedstage myeloma at diagnosis, complications, reduced disease-free survival, and poor patient-reported outcomes.[7,8,9]. Symptoms alone are poorly predictive of myeloma in primary care because the symptoms associated with myeloma are non-specific and common in patients without myeloma. While GPs may not think to investigate myeloma in patients with non-specific symptoms, they often order simple laboratory tests. Patients with myeloma experience substantial delays in their diagnosis, which can adversely affect their prognosis
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