Abstract
Type 2 Diabetes Mellitus (T2DM) is a complicated multifactorial illness involving hereditary and external environmental variables. The symptoms typically appear gradually over a number of years without realizing it. This viewpoint is further supported by the Ayurvedic constitution concept (Prakriti). Prakriti explains the biological variability that is observed in different individuals. This study was conducted a retrospective investigation to examine if there was a link between type 2 diabetes and an individual’s constitution based on anthropometric and biochemical characteristics. Physical and mental characteristics and anthropometric and biochemical markers were used to determine reported cases’ prevailing Dosha Prakriti (constitution). Based on biochemical and anthropometric data, significant differences in Prakriti were found between the case (T2DM patients) and control (person without diabetes) groups. The incidence of numerous secondary problems linked with T2DM patients was also evaluated according to their Prakriti types, which revealed a positive relationship. The three primary contributing parameters, such as waist-hip ratio, postprandial blood sugar, and serum creatinine, were correctly classified all person with or without diabetes subjects to 90.6% of the time, whereas the constitution-wise study classified person with diabetes and without diabetes individuals of Pitta and Kapha Prakriti to 94.3% and 90%, respectively. A discriminant function was created to predict a person with diabetes and without diabetes based on these three contributing factors. The primary contributing biochemical parameters discovered by Prakriti in the current study could be used as a biochemical disease diagnostic for predicting type 2 diabetes susceptibility.
Highlights
Diabetes mellitus (DM) is wreaking havoc on the public health system
Among a total of 112 type 2 diabetes mellitus (T2DM) cases, Pitta (n = 51) and Kapha (n = 60) individuals were grouped according to the dominance of their Dosha Prakriti
112 persons without diabetes were grouped into Vata (n = 17), Pitta (n = 55), and Kapha (n = 40) based on their dominance of Dosha Prakriti
Summary
Diabetes mellitus (DM) is wreaking havoc on the public health system. DM is linked to an elevated risk of numerous types of diseases and malignancies [1]. The disease’s prevalence is anticipated to rise to 623 million by 2045, with type 2 diabetes mellitus (T2DM) accounting for about 90% of cases [2]. Hyperglycemia is a symptom of T2DM caused by insulin resistance and a decrease in insulin production. It is a common disorder with increasing prevalence due to lack of physical activity and increased degrees of obesity [3]. Insulin resistance is a condition that affects body cells such as the muscle, liver, and fat cells; they fail to respond to insulin, even when insulin levels are high. Triglycerides are broken down to produce free fatty acids for energy; muscle cells are deprived of energy sources, and liver cells fail to build up glycogen stores. Hyperglycemia initiates and sustains an injury to many organs and systems, resulting in serious complications such as retinopathy, neuropathy, cardiovascular diseases, nephropathy, peripheral vascular diseases, and periodontal pathologies [5]
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