Abstract
According to Statistics of India in April 2016 population of people above the age of 60 years has increased to 8.6 % of 121 Crores. Age related changes in the Central Nervous System commonly seen in the process of ageing include, Gross brain atrophy, Ventricular enlargement, Selective regional neuronal loss, Remodeling of dendrite, axons and synapses, Appearance of intraneuronal lipofuscin, Selective regional decrease in neurotransmitter and neuropeptides, Selective modification of neurotransmitter metabolism, Possible dysregulation of gaseous neurotransmitter metabolism, Glucocorticoid neurotoxicity, Changes in receptors, Changes in neurotrophins, Changes in signal transduction, Impairment of calcium homeostasis, Possible changes in cell cycle regulations (eg, cyclins), Possible changes in extra cellular matrix proteins (eg. Laminin, proteoglycans), Possible regional decline in cerebral blood flow, Possible regional decline in metabolic rate and Appearance of senile plaque & neurofibrillary tangles.
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