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Abstract
Steady-state pharmacokinetics of valproic acid (VPA) with or without other antiepileptic drug (AED) treatment were studied in 37 children. Children (N=16) receiving multiple AED therapy had a higher clearance (23.5 vs 13.0 ml/hr/kg, P<0.001), larger volume of distribution (0.30 vs 0.22 L/kg, P<0.01), and shorter half-life (9.4 vs 12.3 hours, P<0.01) than did those (n=21) receiving VPA only. Inverse correlations of age with clearance (R=−0.559, P<0.01) and apparent volume of distribution of VPA (r=−0.490, P<0.05) were observed in children receiving monotherapy. In determining the dose and dosing interval of VPA, consider a possible alteration in the pharmacokinetics relating to age and other concurrent AED therapy.
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