Clinical pathology analysis of colon serrated lesions

Abstract

Objective Serrated lesions represent a different kind of lesions, some of which have malignant potential. Understanding the clinical pathological characteristics of serrated lesions is essential for treatment. Methods Based on the morphological observation of pathological changes of 788 cases of colon polyps with immunohistochemical testing, better diagnosis according to the World Health Organization Criteria. According to different detection methods learned that each of the serrated lesions in clinical pathological features, by chi-square test, the difference is statistically significant (P<0.05). Results The ratio of polyp numbers is high (508, 64.6%) , located at the distal colon (381, 75.1%), most associated with acute and chronic inflammatory response (330, 64.9%; 178, 35.1%). But in wide base serrated adenomatous polyps (SSA/P) / (with or without atypical hyperplasia), traditional serrated adenoma (TSA) with more features such as associated with acute and chronic inflammatory response, smooth muscle bundle of lamina propria ingrowth . And clinical characteristics of traditional serrated adenoma, wide base serrated adenoma/polyp with hyperplasia of BRAF testing positive for 44 19 (35.2%). And there is higher percentage (TSA) in patients with bowel disease malignant progression of 42 patients and follow-up health (HP) in the higher percentage of 490 , differences between the two groups have statisticd significance (χ2=21.438, P<0.05). Conclusions The serrated lesions is still insufficient understanded, and the correlation between serrated lesions and colon cancer is not clear. Therefore, precise understanding the serrated lesions is very important for patients with enteroscopy. Key words: Colon; Adenoma; Serrated lesions; Pathology