Clinical, Pathological, Laboratory Characteristics, and Treatment Regimens of Kimura Disease and Their Relationships With Tumor Size and Recurrence.

Lina Fan,Shiyan Mo,Jian Zhu,Yanyan Wang

doi:10.3389/fmed.2021.720144

Lina Fan, Shiyan Mo + Show 2 more

Open Access

https://doi.org/10.3389/fmed.2021.720144

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Abstract

Objective: As of date, Kimura disease (KD) has an unclear etiology, no accepted diagnostic standard, and no definite treatment regimen. In this study, clinical and pathological laboratory characteristics and treatment regimens of patients with KD with different tumor sizes and status of tumor recurrence were analyzed. This was performed to identify the factors, which determine tumor size and recurrence, and to identify effective treatment methods for patients with KD.Methods: A total of 33 hospitalized patients with a definite diagnosis of KD were enrolled in this study.Results: There were 15 patients (45.5%) with a maximum tumor diameter of <3 cm. There were no statistically significant differences in age, gender, clinical symptoms, lesion sites, laboratory indicators, and treatment regimens among patients with a maximum tumor diameter <3 cm or ≥3 cm (P > 0.05). Among the 25 patients who completed the follow-up, there were 18 patients (72%) who had a recurrence of KD. There were no statistically significant differences in age, gender, clinical symptoms, the maximum tumor diameter, lesion sites, laboratory indicators, and initial treatment regimens between patients with or without the recurrence of KD (P > 0.05). There was a statistically significant difference in systolic blood pressure (SBP) between patients with or without the recurrence of KD (P < 0.05). All patients who received only surgical treatment had disease recurrence, 33.3% of patients who received prednisone therapy had no disease recurrence, and 37.5% of patients who received combination therapy showed recurrence.Conclusion: The current study summarized clinical manifestations, pathological features, laboratory indicators, and treatment regimens of patients with KD. There were no significant differences in these aspects among patients with different tumor sizes, and there was no significant difference in these aspects except in the SBP between patients with or without the recurrence of KD, indicating that SBP is a significant clinical factor affecting disease recurrence in patients. Combination therapy with prednisone was found to be superior to surgical treatment.

Highlights

Kimura disease (KD) is a benign, chronic inflammatory granuloma, known as an eosinophilic lymphoid granuloma
The current study found that prednisone remains the cornerstone of treatment for patients with KD, regardless of whether it is combined with other therapies
The current study summarized clinical manifestations, pathological features, laboratory indicators, and treatment regimens of patients with KD

Summary

Introduction

Kimura disease (KD) is a benign, chronic inflammatory granuloma, known as an eosinophilic lymphoid granuloma It manifests mainly through progressive enlargement of a painless mass and is accompanied by the increased levels of eosinophils and immunoglobulin E (IgE) (1). As it is a rare disease in clinical practice, KD has an unknown etiology and unclear pathogenesis. The clinical manifestations, pathological features, laboratory characteristics, and treatment regimens of patients with KD related to tumor size and recurrence have been rarely reported in the previous studies. Clinical, pathological, and laboratory characteristics and treatment regimens of patients with KD with different tumor sizes and status of tumor recurrence were analyzed to identify factors influencing tumor size and recurrence and to identify reasonable and effective treatment methods in patients with KD

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