Clinical, pathological features and treatment of metastatic breast cancer with triple negative breast cancer and its relationship with disease free survival

Abstract

Objective To study the clinical, pathological features and treatment of metastatic breast cancer with triple negative breast cancer(TNBC) and its relationship with disease free survival. Methods One hundred and fifty-eight cases of TNBC patients who were treated in the First Affiliated Hospital of Zhengzhou University and the Chinese Medicine Hospital of Changge from January 2004 to January 2009 were selected as the research objects.All patients received operation and radiotherapy, the relationship between the clinical characteristics, pathological features and treatment with 5, 3 year survival rate, and the recurrence and metastasis of patient were analyzed. Results In clinical stage III period, the 3 years survival rate was 46.51%(20/43), 5 years survival rate was 37.21%(16/43), all significantly lower than in the phase I and II(91.53%(54/59) and 76.27%(45/59); 87.50%(49/56) and 71.43%(40/56)), and the differences were statistically significant(χ2=25.306, 15.787, 19.348, 11.592; P<0.001). With lymph node metastasis, the 3 years survival rate was 66.00%(33/50), 5 years survival rate was 50.00%(25/50), significantly lower than that without lymph node metastasis(83.33%(90/108), 70.37%(76/108)), the difference was statistically significant(χ2=5.954, 6.150; P<0.05). In pathological grade III, the 3 years survival rate was 65.67%(44/67), 5 years survival rate was 43.28%(29/67), significantly lower than that of grade I(92.86%(26/28), 85.71%(24/28)) and grade II(84.13%(53/63), 76.19%(48/63)), the difference was statistically significant(χ2=7.527, 14.414, 5.839, 14.560; P<0.05). The 3 year survival rate of radiotherapy group was significantly higher than that in non radiotherapy group, the difference was statistically significant(81.58%(31/38) vs. 57.69%(15/26); χ2=4.357, P<0.05). Patients with metastatic sites were lung, liver, brain, bone and supraclavicular lymph nodes, the median survival time after the transfer all more than 2 years. Conclusion TNBC is a special type of breast cancer that is difficult to treat, no consensus has been reached on the clinical treatment plan.Breast conserving surgery also has certain application value, radiotherapy only can increase the 3 year survival rate.The clinical stage and pathological grade are the influence factors of prognosis. Key words: Triple negative breast cancer metastasis; Survival rate; Clinical feature; Pathological characteristics; Quality of life