Clinical pathological analysis of the conditions of Helicobacter pylori infection in the gastric mucosa biopsy sections

Abstract

Objective To analyze and investigate the relationship between Helicobacter pylori (Hp) infection and the gastric mucosa diseases and their pathological changes.Methods The gastric mucosa biopsy sections from 700 patients with gastric mucosa diseases were selected as the study objects.Hp infection of the biopsy sections was detected by Giemsa staining and Warthin-Starry staining method and the relationship between Hp infection and the gastric mucosa diseases and the pathological changes was analyzed.Results Among all 700 sections,there were 463 cases of Hp positive sections and the Hp positive detective rate was 66.14％.The Hp detection rates of the gastric mucosa biopsy sections from patients with chronic superficial gastritis,chronic atrophic gastritis,gastric ulcer and gastric cancer were 46.86％,69.46％,83.62％ and 98.65％.The overall difference of the Hp detection rates of the gastric mucosa biopsy sections from patients with each of the four diseases and the differences between every two diseases were significant (P ＜ 0.05) ; by analyzing the pathology changes and Hp infection of the gastric mucosa biopsy sections,the results showed the Hp infection rate of the gastric mucosa biopsy sections in which the pathological changes was atrophic changes,active changes,intestinal metaplasia,atypical hyperplasia of glandular epithelium,lymphoid follicles increased significantly (P ＜ 0.05).Conclusions Hp infection is correlated with the gastric mucosa diseases such as chronic gastritis,gastric ulcer and gastric cancer and their pathological changes.As the diseases progresses and the pathological structure changes,Hp infection rate showes a rising trend.Therefore,timely treatment of Hp infection is very important for prevention and treatment of gastric mucosal diseases and the progress of their pathological changes. Key words: Helicobacter pylori ; Gastritis ; Pathology