Clinical outcomes of preoperative endoscopic nasobiliary drainage versus percutaneous transhepatic biliary drainage for patients with perihilar cholangiocarcinoma

Abstract

Objective To compare the clinical outcomes of endoscopic nasobiliary drainage (ENBD) versus percutaneous transhepatic biliary drainage (PTBD) in patients with perihilar cholangiocarcinoma. Methods This retrospective case-control study was conducted on 55 patients with perihilar cholangiocarcinoma who were treated by of hepatobiliary and pancreatic surgeons at the Nanjing Drum Tower Hospital between December 2010 and August 2017. Results There was no significant difference in the effectiveness of the two drainage methods (P>0.05). Morbidity after drainage was significantly higher in the ENBD group than the PTBD group (86.7% vs 28.0%, P 0.05). Abdominal infection after surgery was more common in the PTBD group than the ENBD group (64.3% vs 26.3%, P<0.05). Conclusion As PTBD caused catheter tract tumor implantation and increased the incidence of abdominal infection after surgery, ENBD was recommended for patients with perihilar cholangiocarcinoma treated in a tertiary medical center. Key words: Perihilar cholangiocarcinoma; Biliary drainage; Endoscopic nasobiliary drainage; Percutaneous transhepatic biliary drainage