Clinical Outcomes of Older Persons and Persons With Dementia Admitted for Coronavirus Disease 2019: Findings From the Philippine CORONA Study (P2-6.001)

Abstract

<h3>Objective:</h3> We aimed to describe the clinical features of older persons admitted for coronavirus disease 2019 (COVID-19) and to compare their outcomes with other adults with COVID-19. We also aimed to determine the association between dementia and COVID-19 outcomes. <h3>Background:</h3> The Philippine CORONA Study is a multicenter, retrospective, cohort study of 10,881 COVID-19 admissions between February and December 2020. <h3>Design/Methods:</h3> Subgroup analysis was done on clinical outcomes of mortality, respiratory failure, duration of ventilator dependence (DVD), intensive care unit (ICU) admission, length of ICU stay (LICUS), and length of hospital stay (LHS) among older persons and persons with dementia. <h3>Results:</h3> The adjusted hazard ratios (aHRs) for mortality among the mild and severe cases were significantly higher by 3.93, 95% CI [2.81, 5.50] and by 1.81, 95% CI [1.43, 2.93], respectively, in older persons compared to younger adults. The aHRs for respiratory failure in older persons were increased by 2.65, 95% CI [1.92, 3.68] and by 1.27, 95% CI [1.01, 1.59] among the mild and severe cases, respectively. The aHR for ICU admission in older persons was higher by 1.95, 95% CI [1.47, 2.59] among the mild cases. The aHRs for mortality and ICU admission in persons with dementia were higher by 7.25, 95% CI [2.67, 19.68] and by 4.37, 95% CI [1.08, 17.63], respectively, compared to those without dementia. <h3>Conclusions:</h3> Older age and dementia significantly increased the risk of mortality, respiratory failure, and ICU admission among COVID-19 patients. <b>Disclosure:</b> Michelle Anlacan has received personal compensation in the range of $0-$499 for serving as a Consultant for Torrent Philippines. Michelle Anlacan has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Medichem Philippines. Michelle Anlacan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Hi Eisai Philippines. Michelle Anlacan has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Natrapharm Philippines. Michelle Anlacan has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for Alzheimer’s disease association of the philippines. Michelle Anlacan has received research support from Philippine Council for Health Research and Development. Michelle Anlacan has received research support from Philippine Neurological Association. Dr. Piamonte has nothing to disclose. Marie Charmaine Sy has nothing to disclose. Emilio Villanueva III has received personal compensation in the range of $500-$4,999 for serving as a Consultant for LabX Corporation. Roland Dominic Jamora has received personal compensation in the range of $500-$4,999 for serving as a Consultant for torrent. Roland Dominic Jamora has received research support from CCXDP. Dr. Espiritu has nothing to disclose.