Abstract
IntroductionAlzheimer's disease (AD) and COVID‐19 share common risk factors including hypertension. Angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) are frequently prescribed antihypertension medications.MethodsThis study analyzed 436,823 veterans tested for SARS‐CoV‐2 infection. We conducted both classical and propensity score weighted logistic models to compare COVID‐19 outcomes between patients with AD or mild cognitive impairment (MCI) to those without cognitive impairment, and examined effect of ACEI/ARB prescription.ResultsThere was a statistically significant association between AD and increased odds of infection and mortality. MCI was not found to be a risk factor for infection. Subjects with MCI exhibited poor clinical outcomes. Prescribing ARBs but not ACEIs was significantly associated with a lower risk of COVID‐19 occurrence among AD and MCI patients.DiscussionExploring beneficial effects of existing medications to reduce the impact of COVID‐19 on patients with AD or MCI is highly significant.Highlights There is significant association between Alzheimer's disease (AD) and increased risk of COVID‐19 infection and odds of mortality.Subjects with mild cognitive impairment (MCI) defined by claims data exhibit poor clinical outcomes, but MCI was not found to be a risk factor for severe acute respiratory syndrome coronavirus 2 infection.Prescribing angiotensin II receptor blockers was significantly associated with a lower risk of COVID‐19 occurrence among AD/MCI patients.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.