Abstract
The clinical outcome of different chronic obstructive pulmonary disease (COPD) phenotypes is still unclear. This study was designed to detect the effect of different COPD phenotypes on disease outcomes. One hundred stable COPD patients were included. They were divided into 3 phenotypes; 45 patients in exacerbator phenotype, 37 patients in non-exacerbator, and 18 patients in asthma COPD overlap (ACO) phenotype. Patient demo-graphics, respiratory symptoms, grading of COPD, co-morbidities, spirometry, six minute walk test, and systemic inflammatory markers were measured. Also, exacerbation frequency and severity were assessed throughout the study period. COPD Assessment Test (CAT) score was significantly higher in exacerbator phenotype versus the other phenotypes(14.7 ± 1.5; p = 0.04).In addition, about 60% and 42% of exacerbator phenotype were in Global Initiative for Chronic Obstructive Lung Disease (GOLD) class D and C respectively which were significantly higher than the other phenotypes(p = 0.001), while 58% and 50% of non-exacerbator and ACO patients respectively were in class B of GOLD. Twenty eight percent of patients of ACO had no comorbidity and this was significantly higher versus the other phenotypes (p = 0.03), while 40% of non-exacerbator had one comorbidity (p = 0.003) and 86% of exacerbator had ≥ 2 comorbidities (p = 0.002). COPD comorbidity index was significantly higher in exacerbator phenotype (2.5 ± 0.8; p = 0.01). Although patients of exacerbator phenotype had more and severe form of exacerbations than the other phenotypes, no significant difference in in-hospital outcome was found (p = 0.3). Exacerbator phenotype has worse disease outcome than those of non-exacerbator and ACO phenotypes. These results support the need for more treatment options to alleviate the morbidity of COPD especially among exacerbator phenotype.
Highlights
The clinical outcome of different chronic obstructive pulmonary disease (COPD) phenotypes is still unclear
It was found that patients of the exacerbator and nob-exacerbator phenotypes were significantly older than asthma COPD overlap (ACO) patients, male gender was more in exacerbator and non-exacerbator phenotypes
On analysis of post hoc test results, it was found that ACO patients were younger and most of them were females, while their spirometry readings were less affected than the other phenotypes (Table 1)
Summary
The clinical outcome of different chronic obstructive pulmonary disease (COPD) phenotypes is still unclear. Chronic obstructive pulmonary disease (COPD) is a prevalent, preventable and treatable disorder that is specified by constant respiratory features and limitation of airflow that is owing to airway and or alveolar flaws that is created by notable exposure to toxic particles or gases [1]. It is a complex disease and heterogeneous and has multicomponent elements so the concept of phenotype-emerged, and the traditional concept of pink puffers and blue bloaters, is being replaced by a variety of different phenotypes [2]. This study was carried out to highlight on outcomes of these phenotypes purposing to intensify the lines of treatment available for those with the worst outcomes
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
