Abstract
To evaluate the clinical outcomes and dose optimization using CT based planning in gynecological malignancy (Cervical and endometrial cancer) undergoing interstitial (MUPIT) brachytherapy. Material and Methods: 30 patients histologically diagnosed endometrial or cervical malignancy and underwent hysterectomy who received external beam radiation followed by HDR interstitial brachytherapy with MUPIT. The clinical target volume and organs at risk were delineated and optimization done for optimum CTV coverage and sparing of organs at risk. The Coverage Index (CI), dose homogeneity index (DHI), overdose index (OI), dose non-uniformity ratio (DNR), external volume index (EI), conformity index (COIN) and dose volume parameters recommended by GEC-ESTRO were evaluated. The patients were followed up and toxicities were graded as per the RTOG scales and local control rates and disease free survival were evaluated.
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