Clinical Outcome of Neutropenic Colitis in Neutropenic Colitis in Pediatric Patients with Pediatric Patients with Leukemia in a Third Level Leukemia in a Third Level Hospital in Mexico Hospital in Mexico

Abstract

Abstract Objectives To know the incidence and number of To know the incidence and number of patients with complications of patients with complications of neutropenic colitis. neutropenic colitis. Study type and design Descriptive, cross-sectional and retrospective study during the period retrospective study during the period from June 2018 to May 2021. from June 2018 to May 2021. Material and methods In a third level hospital where the In a third level hospital where the population is adults and pediatric in population is adults and pediatric in Mexico city, data were obtained of Mexico city, data were obtained of clinical records of pediatric patients clinical records of pediatric patients with hematological cancer aged 1 to 17 with hematological cancer aged 1 to 17 years of both genders with clinical years of both genders with clinical data of neutropenic colitis. data of neutropenic colitis. For the calculation of the sample, the For the calculation of the sample, the Epi Info program was used with the Epi Info program was used with the formula for descriptive studies and 59 formula for descriptive studies and 59 files are required. Results Total patients 75, male 56%, patients with ALL 87%, the majority of patients had fever and pain 91%, we found ultrasound positive with colitis en 93%, the majority of patients had treatment with cytarabine and methotrexate 60%, the initial treatment for neutropenic colitis was cefepime/metronidazole in 40%, the average days of treatment was 12 days, complications was found in 31%, and the recovery of patients was 100%. Conclusion Patients who are managed with antimetabolites Patients who are managed with antimetabolites have a 10 times greater risk of presenting have a 10 times greater risk of presenting sepsis. sepsis. The main etiological agents continue to be gram The main etiological agents continue to be gram negative microorganisms. negative microorganisms. Despite severe neutropenia, no increase in Despite severe neutropenia, no increase in sepsis was observed. sepsis was observed. It is important to take into account the It is important to take into account the chemotherapy scheme to detect early patients chemotherapy scheme to detect early patients who may be at risk of presenting a complication. who may be at risk of presenting a complication. 13% presented septic shock, however, there 13% presented septic shock, however, there were no reported deaths.