Abstract
Many epidemiological studies have revealed the association between the risk of developing endometrial cancer (EС) and metabolic syndrome (MS) components. A large percentage of patients, especially elderly patients, may have one or more MS components at the time of cancer diagnosis.Objective: to identify the clinical and morphological features of EС, depending on the number of MS components: three-, fourand five-components.Material and Methods. The study included 60 patients with morphologically verified endometrial cancer (T1–3aN0–1M0). All endometrial cancer patients were divided into three groups. Group I included patients with MS, group II – patients with obesity or overweight (ICU ), and group III – patients without MS. Endometrial cancer patients with MS were divided into three subgroups: patients with 3 MS components, with 4 MS components and with 5 MS components.Results. The proportion of endometrial cancer patients with MS was 53.3 %. The median age of the patients was 61.0 ± 2.1 years. The majority of patients had 4 components of MS. Moderately differentiated tumor was observed in 71.8 % of cases, and invasion of less than one-half of the myometrium was observed in 65.3 % of cases. Significant factors of relapse-free survival were: the presence/absence of MS, TG level and the fasting plasma glucose level, thus underlining the effect of MS not only on the development of EС, but also the survival of patients.Conclusions. Our study and many previous studies indicate that the strategies for reducing the prevalence of the components of MS are needed to be developed.
Highlights
Введение Рак эндометрия (РЭ) является шестым наиболее распространенным раком у женщин во всем мире [1]
Many epidemiological studies have revealed the association between the risk of developing endometrial cancer (EС) and metabolic syndrome (MS) components
All endometrial cancer patients were divided into three groups
Summary
Эпидемиологические исследования выявили ассоциации между риском развития рака эндометрия (РЭ) и отдельными компонентами метаболического синдрома (МС). Цель исследования – выявить клинико-морфологические особенности рака эндометрия в зависимости от варианта метаболического синдрома: трех-, черырех- и пятикомпонентного. В исследование были включены 60 больных морфологически верифицированным раком эндометрия I–II стадии (T1–3aN0–1M0), которым проведен стандартный объем обследования. Все больные в зависимости от наличия метаболического синдрома или метаболических нарушений были разделены на три группы: первая группа – больные РЭ с МС, вторая группа – больные РЭ с ожирением или избыточной массой тела, третья группа – больные РЭ без МС. Значимыми факторами безрецидивной выживаемости явились наличие или отсутствие МС, уровень тиреоглобулина и уровень глюкозы плазмы натощак, что еще раз подчеркивает влияние МС не только на развитие РЭ, но и на выживаемость больных. Ключевые слова: рак эндометрия, метаболический синдром, ожирение, избыточная масса тела, выживаемость
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