Abstract
Objective To explore the effect of Wenjing Decoction and Tiaobu Chongren acupuncture and moxibustion therapy on serum sex hormones and ovarian function recovery in premature ovarian failure (POF) patients with deficiency-cold syndrome. Methods From February 2018 to October 2019, 119 POI patients with deficiency-cold syndrome who met the selection criteria were randomly divided into the control group (n = 59) and the observation group (n = 60). The control group was treated with hormone replacement therapy, and the observation group was treated with Wenjing Decoction and Tiaobu Chongren acupuncture and moxibustion therapy on the basis of the control group. Both groups were treated continuously for 3 months. After treatment, the clinical efficacy of the two groups was compared, the Chinese medicine syndrome score, serum estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-mullerian hormone (AMH) and bilateral antral follicle count (AFC), mean ovarian volume, and endometrial thickness of the two groups before and after treatment were compared. Result The effective rate of the observation group (93.10%) was higher than that of the control group (77.59%) (P < 0.05). After treatment, the index scores of traditional Chinese medicine syndromes in two groups were lower than before (P < 0.05), and the observation group was lower than the control group (P < 0.05). The serum E2 and AMH levels in the two groups increased, while FSH and LH levels decreased compared with before treatment, and the observation group improved significantly compared with the control group (P < 0.05). The bilateral AFC, mean ovarian volume, and endometrial thickness of the two groups increased compared with before treatment, and the observation group was higher than the control group (P < 0.05). Conclusion On the basis of hormone replacement therapy, the combination of Wenjing Decoction and Tiaobu Chongren acupuncture and moxibustion therapy is effective in treating POF patients with deficiency-cold syndrome, which can effectively regulate their serum sex hormone levels and promote the recovery of ovarian function.
Highlights
Premature ovarian failure (POF) is an allogenic disease with multiple factors leading to ovarian follicle damage or failure, decreased ovarian reserve function, and persistent amenorrhea with or without perimenopausal syndrome before the age of 40 [1, 2]. is disease causes impaired ovarian function and is prone to secondary infertility and a variety of chronic diseases
The combination of Wenjing Decoction and Tiaobu Chongren acupuncture and moxibustion was applied to POF patients with deficiency-cold syndrome to observe its efficacy in improving traditional Chinese medicine syndrome scores, serum sex hormone levels, and ovarian function. e aim is to seek a better treatment plan for POF with deficiency-cold syndrome and to provide reference for clinical treatment of POF
E pathogenesis of the disease is complex, and factors such as hormones, immunity, genetics, environment, and psychology are involved in the occurrence of POF [12,13]
Summary
Premature ovarian failure (POF) is an allogenic disease with multiple factors leading to ovarian follicle damage or failure, decreased ovarian reserve function, and persistent amenorrhea with or without perimenopausal syndrome before the age of 40 [1, 2]. is disease causes impaired ovarian function and is prone to secondary infertility and a variety of chronic diseases. Is can help some patients rebuild their normal menstrual cycle, relieve symptoms such as hot flashes and night sweats, and prevent long-term complications [6] It has limited efficacy and many contraindications, and when used for a long time, it will increase the risk of breast cancer, ovarian cancer, cervical cancer, and thromboembolism [7]. Tiaobu Chongren acupuncture and moxibustion therapy is one of the external treatments with traditional Chinese medicine characteristics and plays a positive role in the prevention and treatment of women’s gynecological diseases. The combination of Wenjing Decoction and Tiaobu Chongren acupuncture and moxibustion was applied to POF patients with deficiency-cold syndrome to observe its efficacy in improving traditional Chinese medicine syndrome scores, serum sex hormone levels, and ovarian function.
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