Clinical observation on Jawei-Wendan decoction in treating acute exacerbation of chronic obstructive pulmonary disease （AECOPD） due to phlegm blocking in lung

Abstract

Objective To observe the curative effects of Jawei-Wendan decoction in treating acute exacerbation of COPD due to phlegm blocking in lung. Methods From July 2010 to June 2013, 66 enrolled cases were randomly divided into a treatment group and a control group with 33 in each. Aside from receiving anti-infection and symptomatic treatment as the control group did, the treatment group was also given orally Jawei-Wendan decoction. The symptoms, pulmonary function and the variety of the laboratory indexing were observed before and after the treatment. Results ①The treatment group attained better curative effects（P〈0.05） and got shorter symptomatic relief time of cough, expectoration and breathless（The T-value is respectively 16.770, 8.635, 16.762, P〈0.05）. ②After 7-days treatment, the cure rate of the treatment group was 63.64%, and the control group was 39.39%. Their difference was conspicuous（P〈0.05）. The total effective rate in treatment group was 96.97%, which was 90.91% in control group. Their difference was inconspicuous（P〉0.05）.③The pulmonary function indices increased significantly in the treatment group[The values of FEV1、FVC and FEV1/FVC% are （1.41±0.46）L, （2.18±0.63）L and （66.41±6.33）% before treatment, which were （2.21± 0.55）L, （2.83±0.53）L and （77.37±7.64）%after treatment, P〈0.01]. A comparison of the two groups showed significant differences regarding the pulmonary function indices（P〈0.05）. Conclusion Jawei-Wendan decoction had good curative effect in treating acute exacerbation of COPD due to phlegm blocking in lung. Key words: Chronic obstructive pulmonary disease; Phlegm blocking in lung; Jawei-Wendan decoction